The SSCF Swiss Stem Cell Foundation is an independent, non-profit foundation whose goal is to pursue research and development in the domain of stem cells, create new cell therapies for human medical use based on stem cells, as well as to provide training, advice and disseminate knowledge in this field among professional operators and the public at large. The Foundation, moreover, pursues the objective of conducting educational-training programs in the domain of stem cells. This research project is continuing, especially in collaboration with EPFL, for the characterization of those substances produced by these cells which could be the origin of adipose tissue.
Somatic mutations found in the healthy blood compartment of a yr-old woman demonstrate oligoclonal hematopoiesis Abstract The somatic mutation burden in healthy white blood cells WBCs is not well known.
Based on deep whole-genome sequencing, we estimate that approximately somatic mutations accumulated in the nonrepetitive genome within the healthy blood compartment of a yr-old woman. The detected mutations appear to have been harmless passenger mutations: They were enriched in noncoding, AT-rich regions that are not evolutionarily conserved, and they were depleted for genomic elements where mutations might have favorable or adverse effects on cellular fitness, such as regions with actively transcribed genes.
The distribution of variant allele frequencies of these mutations suggests that the majority of the peripheral white blood cells were offspring of two related hematopoietic stem cell HSC clones.
Moreover, telomere lengths of the WBCs were significantly shorter than telomere lengths from other tissues. Together, this suggests that the finite lifespan of HSCs, rather than somatic mutation effects, may lead to hematopoietic clonal evolution at extreme ages.
In the case of this study, life span.
This is different than non genetic differences such as sociocultural factors, lifestyle and accidents. Previous human life span heritability estimates ranged from about 15 to 30 percent. The researchers looked at a carefully chosen set of family trees and relevant information from over million people who were surveyed by Ancestry.
They began with 54 million subscribers to Ancestry which represented six billion ancestors. They then removed entries that were redundant and people who were still living thereby stitching all remaining pedigrees together.
Ancestry then stripped away any identifiable information from pedigrees leaving just the birth year, death year, birth place and familial connections that are part of the family tree structure. Most of the people were based in the U.
The researchers then examined the similarity of life span between relatives so they could estimate heritability from each family tree. They combined statistical and mathematical modeling to analyze data of relatives who were born during the 19th and early 20th centuries.
They observed that first cousins and siblings showed same heritability estimates that were observed in previous studies. They also noted the life spans of spouses were likely to be correlated and were actually more similar than in siblings of opposite gender. The correlation between spouses could be attributed to a variety of non genetic factors such as living in the same household or shared environment.
The results then really started to surprise the researchers when they compared different types of first cousins in laws and siblings in law though there was no blood relatives and typically did not share households.
The researchers were able to focus in on correlations for other even more remote relationships which included uncles in laws and aunts, first cousins that are once removed in law and also a variety of configurations of co siblings in law.
If people did not share genetic backgrounds and also did not share households, then the question became what best accounts for the life span similarity between individuals that had these types of relationships.Stem Cell Research: Should it Continue?
by Tyler Stonell President Bush exercised his first presidential veto against legislation expanding federal funding for stem cell research in Bush said, "If this bill would have become law, American taxpayers would, for the first time in our history, be compelled to fund the deliberate destruction of human embryos.
Moved Permanently. The document has moved here. Despite the controversial stem cell research, companies have promising technology or methodology with the potential for investors to take a closer look in the area. Two recent developments from stem cell research involve the heart and the blood it pumps. In , researchers in Scotland began working on the possibility of generating red blood cells from stem cells in order to create a large supply of blood for transfusions.
Apr 17, · Stem cell research holds incredible healing potential, but embryonic stem cell research isn’t the key to that potential. We should not continue with embryonic stem cell research because it . Aug 09, · Embryonic stem cell research, which uses special cells found in three- to five-day-old human embryos to seek cures for a host of chronic diseases, has sparked a major moral and political debate in the United States.
Until recently, the only way to get pluripotent stem cells for research was to remove the inner cell mass of an embryo and put it in a dish. The thought of destroying a human embryo can be unsettling, even if it is only five days old.
The study, led by researchers at the University of Cambridge, is a step towards developing personalised treatments based on a patient’s own skin cells for diseases of the central nervous system (CNS).
In MS, the body’s own immune system attacks and damages myelin, the protective sheath around nerve fibres, causing disruption to messages sent around the brain and spinal cord. Two recent developments from stem cell research involve the heart and the blood it pumps.
In , researchers in Scotland began working on the possibility of generating red blood cells from stem cells in order to create a large supply of blood for transfusions.